Table 1.

Biotin determinations of urine, CSF and plasma samples

Sample	Proband	Normal range
Urine (pmol/mg creatinine)	429,355	45–118 (n = 49)
CSF (pmol/ml)	88.0	0.022–5.9 (n = 55)
Plasma (pmol/ml)	1,398	0.55–1.1 (n = 80)