| Model animal | Study duration | Target area | Interference of gene therapy |
|---|---|---|---|
| 6-OHDA lesioned rats | 17 weeks | Striatum | Constitutive GDNF expression AAV vector |
| Mifeprestone induced once | |||
| Mifeprestone induced twice | |||
| MPTP-rhesus monkeys monkeys | 12 months | Putamen | AAV2-GDNF vector |
| aged naïve monkeys | 6 months | Putamen substrantial nigra | AAV2-GDNF vector |
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