Table 3.
Treatment period effect between two groups
| 90 days change from baseline (95% confidence interval)
|
Difference | P-value | ||
|---|---|---|---|---|
| NPPV + LTOT | LTOT | |||
| SaO2 | 1.2% (−0.8% to 3.2%) | 0.3% (−0.8% to 1.5%) | 0.9% (−0.6% to 2.4%) | 0.15 |
| FVC | 6.6% (−6.4% to 18.6%) | 6.7% (0.6% to 12.8%) | −0.1% (−5.6% to 23.1%) | 0.20 |
| FEV1 | 17.3% (−8.5% to 43.2%) | −1.4% (−7.7% to 5.0%) | 18.7% (−5.4% to 33.6%) | 0.10 |
| pH | 0.002 (0 to 0.003) | 0.002 (0 to 0.004) | −0.001 (0.001 to 0.002) | 0.56 |
| PaCO2 | −17.7% (−21.5% to −13.9%) | −7.2% (−9.7% to −5.7%) | −10.5% (−4.7% to −12.3%) | 0.03 |
| PaO2 | 4.3% (−4.6% to 13.2%) | −3.1% (−9.6% to 3.5%) | 7.4% (−5.4% to 4.1%) | 0.58 |
| SRI | 24.7% (15.3% to 34.1%) | 5.5% (−0.9% to 11.9%) | 19.2% (2.1% to 17.6%) | 0.21 |
| CAT | −14.7% (−21.3% to −10.2%) | −11.9% (−18.3% to −5.5%) | 6.8% (−20.3% to −4.2%) | 0.06 |
| TDI | −6.9% (9.6% to −4.2%) | −9.4% (−11.9% to −6.9%) | 2.5% (5.3% to −3.2%) | 0.79 |
Abbreviations: CAT, COPD assessment test; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; LTOT, long-term oxygen therapy; NPPV, noninvasive positive pressure ventilation; PaO2, arterial oxygen pressure; PaCO2, arterial carbon dioxide pressure; SaO2, arterial oxygen saturation; SRI, Severe Respiratory Insufficiency; TDI, Transitional Dyspnea Index.