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. 2017 Apr 26;12:3375–3393. doi: 10.2147/IJN.S126310

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© 2017 Zhu et al. This work is published and licensed by Dove Medical Press Limited

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Evaluation of the siRNA/LDL complex and the siRNA–PTX/LDL–NSC–SS–UA micelles.

Notes: (A) RNase protection assay (a); Serum stability of chol-siRNA/LDL (n=3) (b). (B) FT-IR spectra of LDL (a); NSC–SS–UA (b); LDL–NSC–SS–UA (c); LDL and NSC–SS–UA mixture (d). (C) Size distribution and (D) TEM micrograph of siRNA–PTX/LDL–NSC–LA micelles (60,000× original magnification).

Abbreviations: Chol, cholesterol; siRNA, small interfering RNA; LDL, low-density lipoprotein; PTX, paclitaxel; NSC–SS–UA, N-succinyl chitosan–cystamine–urocanic acid; RNase, ribonuclease; FT-IR, Fourier transform infrared spectroscopy; TEM, transmission electron microscope; OD, optical density.