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. 2017 Apr 26;12:3375–3393. doi: 10.2147/IJN.S126310

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© 2017 Zhu et al. This work is published and licensed by Dove Medical Press Limited

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Targeting property and antitumor effect of micelles to MCF-7 tumors in vivo.

Notes: (A) NIR fluorescence real-time images of subcutaneously transplanted MCF-7 tumors treated with (a) Dir/NSC–SS–UA and (b) Dir/LDL–NSC–SS–UA. (B) Tumor volume and (C) relative body weight of mice after treatment with PTX in different formulations at different times. (D) Images and (E) weight of MCF-7 tumors stripped from mice (n=5) (**P<0.01, and ***P<0.005).

Abbreviations: Dir, 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindotricarbocyanine; LDL–NSC–SS–UA, low-density lipoprotein–N-succinyl chitosan–cystamine–urocanic acid; NIR, near infrared spectroscopy; PTX, paclitaxel; siRNA, small interfering RNA.