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. 2017 Apr 26;11:1315–1334. doi: 10.2147/DDDT.S127270

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© 2017 Slastnikova et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Cytotoxic efficiency of ¹¹¹In delivered by FR-targeted MNTs.

Notes: (A) Cytotoxicity of ¹¹¹In-MNT-FA on HeLa cells compared to ¹¹¹In-MNT-PEG-FA. (B, C) Cytotoxicity of ¹¹¹In-MNT-PEG-FA compared to unlabeled MNT-PEG-FA on HeLa (B) and U87MG (C) cells; (D, E) Cytotoxicity of ¹¹¹In-MNT-PEG-FA compared to control ¹¹¹In on HeLa (D) and U87MG (E) cells. (F) Cytotoxicity of ¹¹¹In-MNT-PEG-FA and control ¹¹¹In in the presence or absence of 500 µM free FA on HeLa cells. The solid lines represent fits of the data to a mono-exponential model. Error bars represent standard errors of mean (n=3–6).

Abbreviations: FA, folic acid; MNTs, modular nanotransporters; PEG, polyethylene glycol.