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. 2017 May 3;8:389. doi: 10.3389/fimmu.2017.00389

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Copyright © 2017 Kitaura, Yamashita, Ayabe, Shini, Matsutani and Suzuki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clone sharing among immunoglobulin (Ig) isotypes and subclasses. The proportions of clones shared between two subclasses are shown. Each dot represents an individual. Sequence reads sharing identical V, D, and J segments and identical amino acid sequences of CDR3 were considered as being from identical clonal lineages. The proportions were calculated by dividing the number of shared clones by the total number of ancestral Ig (upstream). Each Ig isotype and subclass is shown in the order corresponding to the genomic location of IGHC regions (22).