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. 2017 May 3;8:389. doi: 10.3389/fimmu.2017.00389

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Copyright © 2017 Kitaura, Yamashita, Ayabe, Shini, Matsutani and Suzuki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Somatic hypermutation (SHM) levels of subclass-specific and shared clones in IgG (A) and IgA (B) subclasses. The frequencies of SHM within the immunoglobulin (Ig) variable region (IGHV) in subclass-specific clones and clones shared among multiple subclasses are shown. Sequence reads found in only an Ig subclass were considered as subclass-specific clones (sp). SHM levels in sequence reads shared between IgG1 and IgG2 (double, a); among IgG3, IgG1 and IgG2 (triple, b); among IgG3, IgG1, IgG2, and IgG4 (quadruple, c); between IgA1 and IgA2 (double, d); and among IgG1, IgA1, IgG2, and IgA2 (quadruple, e) were compared. Statistical significance was tested by Wilcoxon rank-sum test (*P < 0.05, **P < 0.01, and ***P < 0.001).