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Effect of delayed dosing of rolipram on survival. Animals were subjected to CLP and then dosed with rolipram (0.1 mg/kg, ip) or vehicle at 6 h (indicated by the arrow). Survival was monitored through 96 h. Rolipram significantly improved 96-h survival compared to vehicle; ∗p < 0.05 by Log-rank test; n = 14 animal in each group.
