Figure 4.

Loss of Intracellular Negative Regulators of NF-κB/Relish Leads to a Brain-Specific Increase in Expression of AMPs, Locomotor Defects, and Shorter Lifespan

(A–D) A significant increase in AMP gene expression in comparison with yw controls was observed in heads (A) and dissected brains (B) of pirk, trbd, and tg mutants that correlated with a decrease in locomotor activity (C). The shorter lifespan of pirk, but not trbd or tg mutants, was rescued under germ-free (GF) conditions (D). Values shown are mean ± SEM. Asterisks denote statistically significant differences (^∗p ≤ 0.05, ^∗∗p ≤ 0.01, ^∗∗∗p ≤ 0.001).