Table 1.

Reported cases of de novo ANCA-associated glomerulonephritis after kidney transplantation

References	Asif [12]	Tabata [13]	Present case
Age (years), Gender	38, female	34, female	61, female
Type of vasculitis	Granulomatosis with polyangiitis	Microscopic polyangiitis	Microscopic polyangiitis
Causes of ESRD	Unknown (ANCA negative)	IgA nephropathy	CGN
Latency period after KTx	14 years	14 years and 10 months	31 years
Immunosuppressants at diagnosis (daily doses)	mPSL 4–6 mg (alternatively), CsA 225 mg	mPSL 2 mg, MZR 100 mg, Tac 4 mg	PSL 5 mg, MZR 50 mg
ANCA titer	PR3-ANCA 1:320, MPO-ANCA >100 U/mL	MPO-ANCA 12 U/mL	MPO-ANCA 45.5 U/mL
Baseline sCr (mg/dL)	2.4	1.0	0.6
sCr at diagnosis (mg/dL)	2.6	2.4	1.27
Urinary abnormalities	UP 3+, RBC 50–100/HPF	UP 1+, RBC 10–19/HPF	UP 2+, RBC >100/HPF
Allograft biopsy findings	Crescentic glomerulonephritis with necrotizing arteritis	Crescentic glomerulonephritis	Crescentic glomerulonephritis
Extra-renal manifestation	Subarachnoid hemorrhage	None	None
Treatment	Intravenous mPSL (1000 mg × 3 days), CP 125 mg/day	Intravenous mPSL (500 mg × 3 days)	Intravenous mPSL (500 mg × 3 days)
Follow-up period	6 months	5 years	2 years
Graft outcome	sCr 4.0 mg/dL at the last observation	Graft loss	sCr 1.1 mg/dL at the last observation

AZA azathioprine, CGN chronic glomerulonephritis, CP cyclophosphamide, CsA cyclosporine A, ESRD end-stage renal disease, HPF high power field, KTx kidney transplantation,  mPSL methylprednisolone, MZR mizoribine, PSL prednisolone, RBC red blood cell, sCr serum creatinine, Tac tacrolimus, UP urinary protein