Table 4.

Summary of the findings of renal pathology

	1st biopsy	2nd biopsy	3rd biopsy
Time of biopsy	13 years old Abnormality of urinalysis in regular checkup at school	29 years old After the delivery of her 1st child	31 years old Exacerbation of urine protein
Urinalysis and renal function	UP (2+) U-RBC >100/HPF Ccr 162.5 ml/min/1.73 m2	UP 4.8 g/day U-RBC 5–9/HPF Ccr 103.9 ml/min/1.73 m2	UP 1.28 g/day U-RBC 30–49/HPF Ccr 130.3 ml/min/1.73 m2
Hypocomplementemia	Negative, but continuous hypocomplementemia was detected 1 year previously	Negative	Positive, and recovered after corticosteroid therapy
Serum IgM (mg/dl)	1064.2	787.0	657.0
Rheumatoid factor (IU/ml)	2030	1100.9	1108.1
Cryoglobulin	Negative	Positive	Negative
Light microscopy	Minor glomerular abnormalities	Diffuse global mild mesangial proliferation and endotheliosis GBM double contour Global sclerosis 3/24	Lobular formation GBM double contour Endocapillary hypercellularity Global sclerosis 6/26
Immunofluorescence microscopy	IgM and C3 in the mesangial region and part of the capillary wall	IgM and fibrinogen in the mesangial region and part of the capillary wall	IgM, C3, C4, and C1q in the mesangial region and capillary wall
Clinical course	Prednisolone (0.6 mg/kg) Proteinuria and microscopic hematuria continued	Angiotensin II receptor blocker and proteinuria disappeared	Methylprednisolone pulse and prednisolone (0.5 mg/kg) and proteinuria and hematuria disappeared