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. 2017 Apr 28;23(16):2891–2898. doi: 10.3748/wjg.v23.i16.2891

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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Detection of ITGA6 and ITGA6A in stool samples of controls and patients diagnosed with Ad and stage II-IV CRC by duplex qPCR. A: For total ITGA6, significant increases in copy number were observed for Ad and all tested CRC stages relative to Ctrl; B: ROC curve analysis of ITGA6 detection in Ad and in stages II-III CRC. AUC, sensitivity and specificity are provided (95%CI); C: For ITGA6A, significant increases in copy number were only observed for stage II and stage III CRC relative to Ctrl; D: Accordingly, ITGA6A/ITGA6 ratios were found to be significantly different between controls and stage II and III CRC. Results in A, C and D are expressed as median (interquartile range) of copy number relative to control patients. ^aP < 0.05, ^cP < 0.01, ^eP < 0.001 using the Kruskal-Wallis test followed by Dunn’s multiple comparison test.