Table 2.
Substitution rates estimated for the complete coding sequence and for individual genes of CHIKV Asian lineages.
| Substitution rate (95% HPD)/ × 10−4 subs/site/yr |
|||
|---|---|---|---|
| Data set | Asian149 |
Asian50 | |
| Region | Asian genotype | Asian/ American lineage | Asian lineages paraphyletic to Asian/ American lineage |
| Complete cds | 4.6 (4.1–5.2) | 5.0 (2.9–7.9) | 4.4 (3.8–5.0) |
| CP1 + 2 of complete cds | 0.6 (0.6–0.7) | 0.8 (0.6–0.9) | 0.6 (0.5–0.6) |
| CP3 of complete cds | 5.5 (5.2–5.7) | 4.9 (4.4–5.5) | 5.8 (5.5–6.0) |
| C | 4.2 (3.0–6.0) | 5.0 (2.0–9.0) | 3.7 (2.3–5.3) |
| 6k | 10 .0 (6.0–20.0) | 11.0 (3.0–20.0) | 2.6 (0.3–8.1) |
| E1 | 6.0 (4.0–8.0) | 8.0 (1.0–19.0) | 5.3 (3.5–7.2) |
| E2 | 7.0 (5.0–8.0) | 9.0 (3.0–13.0) | 5.7 (4.2–7.3) |
| E3 | 6.0 (3.0–9.9) | −a | 6.6 (2.3–12.2) |
| nsP1 | 4.0 (3.0– 5.0) | 5.0 (2.0–8.0) | 3.7 (2.6–4.8) |
| nsP2 | 4.0 (3.0– 5.0) | 4.0 (3.0–6.0) | 4.2 (3.2–5.0) |
| nsP3 | 7.0 (6.0–9.0) | −a | 6.0 (4.5–7.5) |
| nsP4 | 4.0 (3.0– 5.0) | −a | 4.5 (2.5 – 17.1) |
aThe Asian/American lineage was not apparent as a distinct clade in phylogenies based on these gene regions.