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. 2017 Mar 21;242(1):7–9. doi: 10.1002/path.4876

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© 2017 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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PATH-4876-FIG-0001-c — MDSC activity in cancer promotion. Different subsets of MDSCs are recruited to the tumour microenvironment and promote tumour progression in several ways: (1) they sustain tumour cell stemness by acting directly on tumour cells (upper panel on the right); (2) they promote blood vessel formation through the secretion of pro‐angiogenetic factors (central panel on the right); (3) they support EMT to enhance metastatic potential (lower panel on the right). HCF, hepatocyte growth factor; MET, epithelial‐mesenchymal transition.