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. 2017 Mar 22;24(5):726–733. doi: 10.1111/ene.13272

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© 2017 Biogen. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Kaplan–Meier estimates of the percentage of patients treated with delayed released dimethyl fumarate (DMF, also known as gastro‐resistant DMF) with clinical no evidence of disease activity (NEDA) (intention‐to‐treat population) in the integrated analysis of DEFINE and CONFIRM over 2 years. P values are based on the log‐rank test. , DMF; , placebo. Hazard ratio (95% CI): DMF vs. placebo = 0.61 (0.52–0.72); P value: DMF vs. placebo = <0.0001. [Colour figure can be viewed at wileyonlinelibrary.com].

Inline graphic — Kaplan–Meier estimates of the percentage of patients treated with delayed released dimethyl fumarate (DMF, also known as gastro‐resistant DMF) with clinical no evidence of disease activity (NEDA) (intention‐to‐treat population) in the integrated analysis of DEFINE and CONFIRM over 2 years. P values are based on the log‐rank test. , DMF; , placebo. Hazard ratio (95% CI): DMF vs. placebo = 0.61 (0.52–0.72); P value: DMF vs. placebo = <0.0001. [Colour figure can be viewed at wileyonlinelibrary.com].