Table 4.

Number of variants and annotations in the Ion Channels Variants Portal per channel and number of disease‐associated variants obtained from the ClinVar and neXtProt databases. The last row presents the proportion of naturally occurring variants from our set of variants for each channel

	SCN1A	SCN2A	SCN3A	SCN4A	SCN5A	SCN8A	SCN9A	SCN10A	SCN11A	Total
Number of observations	535	860	51	1,294	1,063	163	514	119	59	4,658
Number of variants	51	184	7	200	112	27	59	27	5	672
Number of disease‐associated variants	506	50	6	72	529	26	62	27	11	1,289
Proportion of natural variants	96%	12%	86%	20%	82%	22%	75%	27%	100%