Figure 2.

Overview of sites reported by the MEME analysis performed on TLR3, TLR9 and TLR25 in the selected species. A schematic drawing of the TLR3 (a), TLR9 (b) and TLR25 (c) protein domains with the ecto-domain (dimerization and ligand interaction), transmembrane (TM) domain and TIR domain (signalling domain). Only the ecto-domain was subjected to selection analysis as the TM and TIR domains are known to be under purifying selection. Grey boxes indicate which parts of the ecto-domain were included in the alignment and also show how many alignments were generated per gene. There is a 22 codon overlap between TLR25 section 2 and 3. Arrows indicate sites reported by the MEME analysis. For site details, see the electronic supplementary material. (Online version in colour.)