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. 2017 Apr 21;8:15089. doi: 10.1038/ncomms15089

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Four major upregulated TF groups and their accordingly GO pathways in different stages during liver regeneration. GO terms were enriched using the TGs that were regulated by at least two TFs in the sub-clusters and expressed in according PHx data. (b) Four major functions categories of outlier TFs, namely immune and stimulus response, development and differentiation, nuclear receptors and metabolism, repressors and brakes. (c) Enrichment of downregulated and upregulated ttmTFs at each time point after PHx. The ttmTFs were significantly downregulated. The levels of downregulated and upregulated non-ttm TFs were used as the baseline. The P values were calculated using Fisher's exact test, *P<0.1, **P<0.01. (d) Dynamic change of six hepatocyte nuclear factors in ttmTF group during liver regeneration.