Table 1. Overlap of ttmTFs with known TFs involved in iPS cell transforming.

Species	TFs	Starting cells	Target cells	Reference
Human	OCT4	Human dermal fibroblasts	Blood progenitors	50
	ASCL1, LMX1A and NR4A2	Human fibroblasts	Dopaminergic neurons	51
	OCT4, SOX2, KLF4 and c-MYC	Human fibroblasts	Endothelial cells	52
	GATA4, MEF2C and TBX5	Cardiac fibroblasts	Cardiomyocytes	53
	SOX2	Fetal foreskin fibroblasts	Neural stem cells	54
	PRDM16 and CEBPB	Skin fibroblasts	BAT	55
	NEUROD1, ASCL1, BRN2, MYT1L, LHX3, HB9, ISL1 and NGN2	Fetal foreskin fibroblasts	Spinal motor neurons	41
Mouse	Ascl1, Brn2 and Myt1l	MEFs, TTFs	Neurons	56
	Sox2, Foxg1 and Brn2	MEFs	Neural precursor cells	57
	Hnf4a+ Foxa1, Foxa2 or Foxa3	MEFs, dermal fibroblasts	Hepatocytes	58
	Ascl1, Lmx1a and Nurr1	Mouse fibroblasts	Dopaminergic neurons	51
	Nr5a1, Wt1, Dmrt1, Gata4 and Sox9	MEFs	Embryonic Sertoli-like cells	59
	Gata4, Mef2c and Tbx5	TTFs	Cardiomyocytes	53
	Sox2	MEFs	Neural stem cells	54
	Ngn3, Pdx1 and Mafa	Pancreatic exocrine cells	Islet β-cells	60
	Gata4, Hnf1a and Foxa3	TTFs	Hepatocytes	40
	Prdm16 and Cebpb	Skin fibroblasts	BAT	55
	Ngn3	Hepatic progenitor cells	Neo-Islets	61
	Sox10, Olig2 and Zfp536	MEFs	Oligodendroglial cells	62
	Ascl1, Brn2, Myt1l, Lhx3, Hb9, Isl1 and Ngn2	MEFs	Spinal motor neurons	41

The ttmTFs are marked in bold. BAT, brown adipose tissue; MEFs, mouse embryonic fibroblasts; TTFs, tail-tip fibroblasts.