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. 2017 Apr 21;8:15074. doi: 10.1038/ncomms15074

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Copyright © 2017, The Author(s)

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(a) SLC7A11 protein levels in SLC7A11-knockdown Hs578T and SLC7A11-overexpressing SK-BR-3 cells. (b,c) Metabolic status under glucose-replete conditions. The OCR (b) and OCR/ECAR ratio (c) were measured in the presence of 10 mM glucose+2 mM glutamine. Data represent the means±s.d. (n=3). (d,e) Cell viability 24 h after glucose withdrawal. SLC7A11 knockdown Hs578T (d) and SLC7A11-overexpressing SK-BR-3 cells (e) were cultured in glucose-deficient medium for 24 h. The following drugs were added as indicated: 500 μM SASP, 0.5 mM AOA, 50 μM EGCG, 10 μM BPTES or 4 mM dm-αKG. Data represent the means±s.d. (n=3).