Table 1. Hit rates from fragment screens before and after use of PanDDA.

Protein	JMJD2D	BAZ2B	SP100	BRD1
Data sets	226	200	116	292
Resolution range (Å)	1.1–2.6	1.5–2.5	1.3–2.7	1.5–3.6
Identified hits (Human/PanDDA)	2/24	3/9	0/2	29/40
Identified hit rate (%) (Human/PanDDA)	0.9/10.6	1.5/4.5	0/1.7	9.9/13.7
Identified sites (Human/PanDDA)	1/5	1/1	0/1	1/2

PanDDA, Pan-Data set Density Analysis.

All fragment screens consisted of a single soaked compound per data set. An identified site comprises more than two binding ligands that are not heavily interacting with crystal contacts. Number of hits was determined as number of data sets containing a bound ligand. Hit rate was calculated as percentage of data sets containing bound ligands.