Table 3.
Cox Proportional Hazard Model of Risk Factors for Death in 42634 Solid Organ Transplant Recipients
| Univariable Analysis | Multivariable Analysis | |||
|---|---|---|---|---|
| Risk Factor | HR (95% CI) | P | HR (95% CI) | P Value |
| Cryptococcosis | 2.57 (1.89–3.50) | <.001 | 2.29 (1.68–3.11) | <.001 |
| Cryptococcal Meningitis | 2.54 (1.60–4.04) | <.001 | ||
| Age | ||||
| 18–40 years | 1.00 | |||
| 41–50 years | 1.46 (1.30–1.65) | <.001 | 1.36 (1.19–1.53) | <.001 |
| 51–60 years | 2.01(1.81–2.24) | <.001 | 1.60 (1.43–1.80) | <.001 |
| 60–70 years | 2.77 (2.48–3.09) | <.001 | 2.29 (2.04–2.57) | <.001 |
| >70 years | 3.32 (2.87–3.85) | <.001 | 3.70 (3.14–4.30) | |
| Female sex | 0.95 (0.89–1.01) | .596 | ||
| Type of transplant | ||||
| Kidney | 1.00 | 1.00 | ||
| Liver | 2.67 (2.47–2.87) | <.001 | 2.47 (2.26–2.71) | <.001 |
| Lung | 4.86 (4.41–5.37) | <.001 | 3.68 (3.28–4.12) | <.001 |
| Heart | 2.47 (2.21–2.76) | <.001 | 2.32 (2.11–2.65) | <.001 |
| Others (multiorgan) | 3.35 (2.88–3.89) | <.001 | 2.21 (1.86–2.65) | <.001 |
| Type of Insurance > 70 years | ||||
| Medicaid/Self-pay | 1.46 (1.28–1.56) | <.001 | 1.24 (1.13–1.37) | <.001 |
| Prior transplant failure/rejection | 2.66 (2.46–2.86) | <.001 | 2.53 (2.38–2.77) | <.001 |
| Other comorbidities | ||||
| Diabetes mellitus | 1.27 (1.20–1.36) | <.001 | 1.14 (1.07–1.21) | .001 |
| Renal failure | 1.66 (1.53–1.80) | <.001 | ||
| Chronic pulmonary disease | 1.31 (1.20–1.44) | <.001 | ||
| Obesity | 1.04 (0.94–1.15) | .484 | ||
| Congestive heart failure | 1.68 (1.54–1.83) | <.001 | 1.58 (1.47–1.73) | <.001 |
| Liver disease | 1.41 (1.24–1.60) | <.001 | 1.22 (1.05–1.42) | .007 |
| Connective tissue disorder | 0.83 (0.70–0.98) | .020 | ||
| Solid tumors | 1.51 (1.12–2.04) | .006 | ||
| Hypertension | 0.52 (0.49–0.56) | <.001 | 0.87 (0.80–0.94) | <.001 |
| Hematological malignancies | 1.65 (1.11–2.48) | .013 | ||
| Cancer with metastasis | 1.95 (1.27–2.99) | .002 | ||
| Valvular heart disease | 1.52 (1.39–1.66) | <.001 | ||
| Depression | 1.38 (1.26–1.52) | <.001 | ||
| Pulmonary circulation disorder | 2.12 (1.95–2.31) | <.001 | ||
| Weight loss | 2.07 (1.90–2.27) | <.001 | 1.22 (1.11–1.34) | <.001 |
| Peripheral vascular disease | 1.34 (1.38–1.69) | <.001 | 1.46 (1.32–1.62) | <.001 |
| Electrolyte disorders | 1.51 (1.42–1.62) | <.001 | 1.18 (1.11–1.26) | <.001 |
| Psychoses | 1.48 (1.26–1.75) | <.001 | 1.21 (1.02–1.42) | .022 |
| Drug abuse | 1.57 (1.33–1.81) | <.001 | 1.20 (1.05–1.39) | .006 |
| Neurological disorders | 1.20 (1.06–1.36) | .002 | ||
| Prior transplantation | 1.23 (1.05–1.43) | .008 | ||
Abbreviations: CI, confidence interval; HR, hazard ratio.