Table 4.
Results of a Positive Screen for Cognitive Impairment in Irish Patients Only
| Characteristics | Positive Screen | Negative Screen | P Value | |||
|---|---|---|---|---|---|---|
| (n = 194) | (n = 234) | |||||
| n | (%) | n | (%) | |||
| Gender | Male | 157 | (43.3) | 206 | (56.7) | .041 |
| Female | 37 | (56.9) | 28 | (43.1) | ||
| Mode of transmission | Heterosexual | 43 | (45.7) | 51 | (54.3) | .000486 |
| MSM | 89 | (37.7) | 147 | (62.3) | Std residual for IVDU was 2.7 | |
| IVDU | 55 | (64.7) | 30 | (35.3) | ||
| Vertical | 0 | (0) | 1 | (100) | ||
| Other | 7 | (58.3) | 5 | (41.7) | ||
| Virally suppressed (n = 504) | Yes | 134 | (41.9) | 186 | (58.1) | .00029 |
| Hepatitis C | Yes | 68 | (64.2) | 38 | (35.8) | .000007 |
| Hepatitis C PCR positive (n = 118) | Yes | 48 | (72.7) | 18 | (27.3) | .000003 |
| Hypercholesterolaemia | Yes | 23 | (30.3) | 53 | (69.7) | .004 |
| Neuropathy | Yes | 4 | (21.1) | 15 | (78.9) | .034 |
| Stroke | Yes | 4 | (100) | 0 | (0) | .041 |
| Depression | Yes | 67 | (54.5) | 56 | (45.5) | .016 |
| Lipid-lowering therapy | Yes | 17 | (29.8) | 40 | (70.2) | .015 |
| Methadone | Yes | 52 | (77.6) | 15 | (22.4) | <.000001 |
| Benzodiazepines | Yes | 62 | (84.9) | 11 | (15.1) | <.000001 |
| Antidepressants | Yes | 39 | (61.9) | 24 | (38.1) | .006 |
| Antipsychotics | Yes | 14 | (82.4) | 3 | (17.6) | .002 |
| Employment history | Employed | 73 | (32.6) | 151 | (67.4) | <.000001 |
| Student | 7 | (30.4) | 16 | (69.6) | ||
| Unemployed | 105 | (65.6) | 55 | (34.4) | ||
| Retired | 9 | (42.9) | 12 | (57.1) | ||
| Smoking history | Smoker | 125 | (55.1) | 102 | (44.9) | .000037 |
| Nonsmoker | 35 | (30.2) | 81 | (69.8) | ||
| Ex-smoker | 34 | (40) | 51 | (60) | ||
| Illicit substance use | Never | 92 | (38.3) | 148 | (61.7) | .002 |
| Current non-IV Use | 49 | (60.5) | 32 | (39.5) | Std residual for current non-IV | |
| Current IV use | 5 | (71.4) | 2 | (28.6) | use was 2 | |
| Previous Hx | 48 | (48) | 52 | (52) | ||
| Positive screen for anxiety | Yes | 62 | (53.4) | 54 | (46.6) | .04 |
| Positive screen for depression | Yes | 31 | (67.4) | 15 | (32.6) | .003 |
| Nadir CD4 count | Mean (SD) | 221.375 (158.8195) | 252.85 (165.0894) | .047 | ||
| Median | 207.5 | 236 | 95% CI, −62.56 to −0.383 | |||
| Current CD4 count | Mean (SD) | 554.887 (281.9671) | 603.721 (236.9321) | .007 | ||
| Median | 521 | 587 | 95% CI, −98.1909 to −0.522 | |||
| Years of education | Mean (SD) | 13.041 (4.0679) | 14.449 (3.5132) | <.001* | ||
| Median | 12 | 14 | ||||
| HADS - Anxiety score | Mean (SD) | 8.619 (4.5055) | 7.333 (4.1319) | .002* | ||
| Median | 8.5 | 7 | ||||
Abbreviations: CI, confidence interval; HADS, Hospital Anxiety and Depression Scale; Hx, history; IV, intravenous; IVDU, intervenous drug users; MSM, men who have sex with men; SD, standard deviation; Std, standardized.
*
Performed using Mann-Whitney U tests and no confidence intervals available for the difference.