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. 2016 Mar 29;21(7):903–909. doi: 10.1038/mp.2016.28

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Parameters estimates from bivariate AE twin models for type 2 diabetes and depression, using the Swedish twin sample, with age as a covariate. Best-fit full sex-limitation bivariate AE model fit to Swedish data in opposite-sex dizygotic twins. Asterisk indicates a significant pathway. A indicates addictive genetic effects; E for unique environmental effects; subscript _DM for type 2 diabetes; subscript _D for depression DM; M for males and F for females. Additive genetic and unique environment contributions to type 2 diabetes and depression are indicated by A_DMM, A_DM, E_DMM and E_DM in males, and by A_DMF, A_DF, E_DMF and E_DF in females, respectively.