Table 3.
Top 10 neoantigens with the highest mutation frequency in 9155 donors.
| gene | HLA allele | position | peptide | mutation | affinity (nM) | mutation frequency |
|---|---|---|---|---|---|---|
| KRAS | HLA-A*02:01 | 8 | KLVVVGADGV | G12D | 214 | 322 out of 9155 |
| KRAS | HLA-A*02:01 | 8 | KLVVVGAVGV | G12 V | 112 | 239 out of 9155 |
| KRAS | HLA-A*02:01 | 8 | KLVVVGAV | G12 V | 163 | 239 out of 9155 |
| KRAS | HLA-B*40:01 | 11 | TEYKLVVVGAV | G12 V | 90 | 239 out of 9155 |
| KRAS | HLA-C*03:04 | 3 | GAVGVGKSAL | G12 V | 172 | 239 out of 9155 |
| KRAS | HLA-C*03:03 | 3 | GAVGVGKSAL | G12 V | 172 | 239 out of 9155 |
| PIK3CA | HLA-C*07:02 | 2 | ARHGGWTTKM | H1047R | 218 | 200 out of 9155 |
| PIK3CA | HLA-C*06:02 | 3 | ARHGGWTTKM | H1047R | 457 | 200 out of 9155 |
| PIK3CA | HLA-C*07:01 | 2 | ARHGGWTTKM | H1047R | 249 | 200 out of 9155 |
| PIK3CA | HLA-A*11:01 | 11 | STRDPLSEITK | E545 K | 81 | 182 out of 9155 |