Fig. 1.

Antemortem infection dynamics in steers following aerosol-inoculation with distinct strains of FMDV-A24-Cruzeiro: a FMDV-WT (n = 20) or b FMDV-Mut (n = 9). a & b FMDV RNA detection in serum, oral and nasal swabs was performed through qRT-PCR, and is presented as log₁₀ genome copy numbers (GCN)/ul. Data presented are average values (mean +/− SEM) based on samples collected from all cattle included at each time point. Virus isolation (VI) was performed on BHK-21 cells and is presented as the percentage of VI positive samples per time point. High GCN/ul of RNA and VI percentage positivity immediately after inoculation indicates detection of residual inoculated virus. * X-axes scales are non-linear. For FMDV-Mut, nasal swab data is derived entirely from animals 699, 9106, 9107, 1003, 1024, and 1025