Table 2.
FMDV-Mut tissue distribution
| Time point (hpi) | 24 | 48 | 72 | |||
|---|---|---|---|---|---|---|
| Animal ID | 699 | 9106 | 9107 | 1003 | 1024 | 1035 |
| Clinical score | 0 | 0 | 0 | 0 | 0 | 0 |
| FMDV RNA copies/μl in serum | neg | neg | neg | neg | neg | neg |
| Tissue sample | ||||||
| Oral cavity/oropharynx | ||||||
| Anterior tongue | - | - | - | - | - | - |
| Lingual tonsil | - | - | - | - | 3.15 | - |
| Anterior hard palate | NA | - | - | - | - | - |
| Palatine tonsil | NA | - | - | - | 3.14 | - |
| Ventral soft palate-Caudal | - | - | - | - | 3.87 | - |
| Nasal cavity/Nasopharynx | ||||||
| Nasal turbinates-posterior | - | - | - | - | - | - |
| Dorsal soft palate -Rostral | + | 2.85 | 3.16 | - | 3.73 | - |
| Dorsal soft palate -Caudal | 2.68 | 4.74 | 4.15 | 2.83 | 4.38 | 2.95 |
| Dorsal nasopharynx -Rostral | 4.43 | - | - | - | 3.01 | 3.07 |
| Dorsal nasopharynx -Caudal | + | 2.57 | 4.54 | - | 3.42 | 3.05 |
| Nasopharyngeal tonsil | - | - | - | + | - | - |
| Ventral epiglottis | - | - | 4.31 | - | 4.10 | - |
| Larynx | 2.70 | - | 2.75 | 5.12 | 3.10 | - |
| Lungs/Trachea | ||||||
| Trachea −10 cm | - | - | - | - | - | |
| Proximal cranial lobe | NA | - | 3.47 | 4.09 | 4.79 | 2.96 |
| Mid cranial lobe | NA | - | 3.86 | 3.13 | 2.68 | 3.91 |
| Distal cranial lobe | 3.36 | 2.57 | + | 3.00 | 4.26 | 3.98 |
| Proximal mid lobe | NA | - | 3.95 | 3.22 | 5.55 | 3.90 |
| Mid mid lobe | NA | - | 5.56 | 3.52 | 4.25 | 3.92 |
| Distal mid lobe | 3.78 | - | 3.47 | - | 3.54 | 3.22 |
| Proximal caudal lobe | NA | - | 4.99 | 4.08 | 4.75 | 3.73 |
| Mid caudal lobe | NA | 3.49 | - | 3.40 | 4.27 | - |
| Distal caudal lobe | 3.62 | 3.04 | 3.43 | - | 3.31 | - |
| Additional tissues | ||||||
| Interdigital cleft | NA | - | - | - | - | - |
| Medial Retropharyngeal LN | NA | - | - | - | + | - |
| Submandibular LN | NA | - | - | - | 2.57 | - |
| Hilar LN | NA | - | - | - | 2.98 | - |
Tabulated Numbers indicate FMDV RNA genome copy numbers (GCN) per mg of tissue
Bold and underlined text indicates infectious virus isolated
‘+’ indicates infectious virus isolated without concurrent detection of FMDV genome
‘-’ indicates negative for detection of FMDV RNA and infectious virus