Table 3.
Characteristics of surgical and antimicrobial therapy
| Debridement and retention n = 18 n |
Revision n = 18 n |
Total n = 36 n |
|
|---|---|---|---|
| Surgery | |||
| Duration of surgery, minutes; median (range) | 34 (18-94) | 1 71 (90-290) | 91 (18-290) |
| Gentamicin beads used | 9 (53) | - | |
| Bone impaction grafting | - | 15 (83) | |
| Complete / partial revision | - | 6 (33) / 12 (67) | |
| Antimicrobial therapy | |||
| Prior intravenous antibiotics | 12 | 9 | 21 |
| Duration of iv therapy, days; median (range) | 11 (2 - 56) | 12 (2 - 15) | 11 (2-56) |
| Duration of iv + oral antibiotic therapy, days; med (range) | 101 (31 – 239) | 92 (80 – 139) | 98 (31-239) |
| < 90 days | 3 | 2 | 5 |
| Hip PJIa, median (range) | 98 (31-146) | 92 (80-139) | 95 (31-146) |
| Knee PJI, median (range) | 182 (117-239) | - | |
| Rifampin dose reduction (300 mg twice daily) | 3 | 3 | 6 |
| Clindamycin-rifampin discontinuation | 3 | 2 | 5 |
| Due to: | |||
| Comorbidities | 2 | 1 | 3 |
| Side effects | |||
| Allergy/Rash | 2 | 1 | 3 |
| Nausea | 2 | 1 | 3 |
| Diarrhea | 0 | 2 | 2 |
| Treatment outcomes | |||
| Failures | 4 | 1 | 5 |
| Successfully treated | 14 (78%) | 17 (94%) | 31 (86%) |
| Patients completed clindamycin-rifampin regimen | 15 | 16 | 31 |
| ➜ Successfully treated | 14 (93%) | 15 (94%) | 29 (94%) |
aPJI, Periprosthetic Joint Infection