Table 3.

Clinical variables of interest and CIMP concordance status

Variable	Metastasis − primary− (n = 64)		Metastasis − primary+ (n = 1)		Metastasis + primary− (n = 0)		Metastasis + primary+ (n = 5)		*P value
	N	%	N	%	N	%	N	%
Age									0.52
Mean (range)	61.0	[24.2, 79.9]	74.4	[74.4, 74.4]			60.6	[51.1, 66.8]
Missing	8		0		0		0
Sex									0.36
Female	30	50%	1	100%			1	20%
Male	30	50%	0	0			4	80%
Missing	4		0		0		0
Stage at diagnosis									>0.99
I	0	0	0	0			0	0
II	6	11%	0	0			0	0
III	13	23%	0	0			1	20%
IV	37	67%	1	100%			4	80%
Missing	7		0		0		0
Primary site									>0.99
Right	12	21%	0	0			1	20%
Left	45	79%	1	100%			4	80%
Missing	7		0		0		0
Histological grade									0.21
Grade 1–2	35	66%	1	100%			5	100%
Grade 3	18	34%	0	0			0	0
Missing	11		0		0		0
Mucinous features									0.10
No	45	82%	1	100%			2	40%
Yes	10	18%	0	0			3	60%
Missing	9		0		0		0
Lymphovascular invasion									>0.99
No	38	72%	1	100%			4	80%
Yes	15	28%	0	0			1	20%
Missing	11		0		0		0
Perineural invasion									>0.99
No	40	71%	1	100%			4	80%
Yes	12	21%	0	0			1	20%
Not applicable	4	7%	0	0			0	0
Missing	8		0		0		0
Molecular status, mutant
KRAS	22	37%	1	100%	0		1	20%	0.33
BRAF	2	3%	0	0	0		0	0	>0.99
NRAS	2	3%	0	0	0		0	0	>0.99
Mismatch repair status, deficienta			0	0	0		0	0	n/a

*P values for categorical variables calculated with a Fisher’s exact test. P values for continuous variables calculated with an ANOVA

^aMismatch repair status was performed for cases with detected CIMP positivity in the primary and/or metastatic tissue