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. 2017 May 2;18:231. doi: 10.1186/s12859-017-1651-7

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — There is evidence of transcriptional activity for 32 out of 36 well-characterized lncRNAs using the Zipper plot. a Zipper plot and associated statistics for the set of 36 well-characterized lncRNAs proposed by [4] using CAGE-seq data. Even though the visualization contains a +/− 5 kb window, it is clear that the closest CAGE peaks for 26 lncRNAs are within +/− 2.5 kb from the TSS. Both AUZ_right_pval and AUZ_left_pval are smaller than 0.01, suggesting that the set of TSSs are more closely associated with CAGE peaks compared to random regions in the genome. b Heatmap showing the distance between TSSs and CAGE-seq, DNase-seq, H3K4me1, H3K4me3 and H3K27ac peaks. Darker colours represent peaks that are closer to the TSSs. LncRNAs marked with an asterisk do not have enough evidence of transcriptional activity. (nt = nucleotides)