Table 2.
Genotypic and allelic distribution of the NLRP1 gene between all patients (n = 163) and controls (n = 201).
| SNP | Genotype/allele | Case (%) | Control (%) | p valuea(χ2) | OR (95% CI) | p valueb |
|---|---|---|---|---|---|---|
| rs8079034 | CC | 120 (73.6) | 153 (76.1) | 0.752 (0.569) | 1.00 | Referent |
| CT | 37 (22.7) | 43 (21.4) | 0.911 (0.553–1.503) | 0.717 | ||
| TT | 6 (3.7) | 5 (2.5) | 0.654 (0.195–2.193) | 0.491 | ||
| CT + TT | 43 (26.4) | 48 (23.9) | 0.584 (0.300) | 0.876 (0.544–1.409) | 0.584 | |
| C | 277 (85.0) | 349 (86.8) | 0.475 (0.509) | 1.00 | Referent | |
| T | 49 (15.0) | 53 (13.2) | 0.858 (0.565–1.306) | 0.476 | ||
|
| ||||||
| rs878329 | GG | 123 (75.5) | 121 (60.2) | 0.009∗ (9.486) | 1.00 | Referent |
| GC | 35 (21.5) | 70 (34.8) | 2.033 (1.262–3.276) | 0.004∗ | ||
| CC | 5 (3.0) | 10 (5.0) | 2.033 (0.675–6.123) | 0.207 | ||
| GC + CC | 40 (24.5) | 80 (39.8) | 0.002∗ (9.486) | 2.033 (1.290–3.204) | 0.002∗ | |
| G | 281 (86.2) | 312 (77.6) | 0.003∗ (8.782) | 1.00 | Referent | |
| C | 45 (13.8) | 90 (22.4) | 1.801 (1.217–2.667) | 0.003∗ | ||
CI, confidence interval; OR, odds ratio.
a p value for genotype and allele frequencies in cases and controls using 2-sided χ2 test.
b p values adjusted by age and gender using logistic regression.
∗ p < 0.05.