Table 4.
Genotypic and allelic distribution of the NLRP1 gene between female patients (n = 74) and controls (n = 102).
| SNP | Genotype/allele | Case (%) | Control (%) | p valuea(χ2) | OR (95% CI) | p valueb |
|---|---|---|---|---|---|---|
| rs8079034 | CC | 57 (77.0) | 75 (73.5) | 0.513 (1.336) | 1.00 | Referent |
| CT | 14 (18.9) | 25 (24.5) | 1.357 (0.648–2.843) | 0.418 | ||
| TT | 3 (4.1) | 2 (2.0) | 0.507 (0.082–3.133) | 0.465 | ||
| CT + TT | 17 (23.0) | 27 (26.5) | 0.597 (0.280) | 1.207 (0.601–2.425) | 0.597 | |
| C | 128 (86.5) | 175 (86.8) | 0.851 (0.035) | 1.00 | Referent | |
| T | 20 (13.5) | 29 (14.2) | 1.061 (0.574–1.959) | 0.851 | ||
|
| ||||||
| rs878329 | GG | 54 (73.0) | 64 (62.7) | 0.350 (2.009) | 1.00 | Referent |
| GC | 18 (24.3) | 35 (34.3) | 4.641 (0.836–3.219) | 0.150 | ||
| CC | 2 (2.7) | 3 (3.0) | 1.266 (0.204–7.854) | 0.800 | ||
| GC + CC | 20 (27.0) | 38 (37.3) | 0.154 (2.031) | 1.603 (0.836–3.075) | 1.603 | |
| G | 126 (85.1) | 163 (79.9) | 0.206 (1.599) | 1.00 | Referent | |
| C | 22 (14.9) | 41 (20.1) | 1.441 (0.817–2.542) | 0.208 | ||
CI, confidence interval; OR, odds ratio.
a p value for genotype and allele frequencies in cases and controls using 2-sided χ2 test.
b p values adjusted by age and gender using logistic regression.