Table 5.
Genotypic and allelic distribution of the NLRP3 gene between all patients (n = 163) and controls (n = 201).
| SNP | Genotype/allele | Case (%) | Control (%) | p valuea(χ2) | OR (95% CI) | p valueb |
|---|---|---|---|---|---|---|
| rs4612666 | CC | 44 (27.0) | 59 (29.4) | 0.220 (3.026) | 1.00 | Referent |
| CT | 90 (55.2) | 94 (46.8) | 0.779 (0.479–1.266) | 0.313 | ||
| TT | 29 (17.8) | 48 (23.9) | 1.234 (0.675–2.258) | 0.495 | ||
| CT + TT | 119 (73.0) | 142 (70.6) | 0.584 (0.300) | 0.890 (0.562–1.410) | 0.619 | |
| C | 178 (54.6) | 212 (52.7) | 0.616 (0.252) | 1.00 | Referent | |
| T | 148 (45.4) | 190 (47.3) | 1.078 (0.804–1.445) | 0.616 | ||
|
| ||||||
| rs10754558 | CC | 50 (30.7) | 76 (37.8) | 0.313 (2.322) | 1.00 | Referent |
| CG | 84 (51.5) | 89 (44.3) | 0.697 (0.438–1.110) | 0.128 | ||
| GG | 29 (17.8) | 36 (17.9) | 0.817 (0.446–1.496) | 0.512 | ||
| CG + GG | 113 (69.3) | 125 (62.2) | 0.155 (2.025) | 0.728 (0.470–1.128) | 0.155 | |
| C | 184 (56.4) | 241 (60.0) | 0.340 (0.912) | 1.00 | Referent | |
| G | 142 (43.6) | 161 (40.0) | 0.866 (0.644–1.164) | 0.340 | ||
|
| ||||||
| rs2027432 | CC | 151 (92.6) | 180 (89.5) | 0.549 (1.200) | 1.00 | Referent |
| CT | 11 (6.8) | 20 (10.0) | 1.525 (0.708–3.284) | 0.281 | ||
| TT | 1 (0.6) | 1 (0.5) | 0.839 (0.052–13.525) | 0.901 | ||
| CT + TT | 12 (7.4) | 21 (10.5) | 0.308 (1.040) | 1.468 (0.699–3.082) | 0.310 | |
| C | 313 (96.0) | 380 (94.5) | 0.352 (0.867) | 1.00 | Referent | |
| T | 13 (4.0) | 22 (5.5) | 1.394 (0.691–2.812) | 0.354 | ||
CI, confidence interval; OR, odds ratio.
a p value for genotype and allele frequencies in cases and controls using 2-sided χ2 test.
b p values adjusted by age and gender using logistic regression.