Table 6.
Genotypic and allelic distribution of the P2RX7 gene between all patients (n = 163) and controls (n = 201).
| SNP | Genotype/allele | Case (%) | Control (%) | p valuea(χ2) | OR (95% CI) | p valueb |
|---|---|---|---|---|---|---|
| rs3751143 | TT | 94 (57.7) | 127 (63.2) | 0.451 (1.592) | 1.00 | Referent |
| TG | 59 (36.2) | 66 (32.8) | 0.828 (0.533–1.287) | 0.401 | ||
| GG | 10 (6.1) | 8 (4.0) | 0.592 (0.225–1.558) | 0.288 | ||
| GT + GG | 69 (42.3) | 74 (36.8) | 0.284 (1.148) | 0.794 (0.520–1.211) | 0.284 | |
| T | 247 (75.8) | 320 (79.6) | 0.215 (1.537) | 1.00 | Referent | |
| G | 79 (24.2) | 82 (20.4) | 0.801 (0.564–1.138) | 0.215 | ||
|
| ||||||
| rs208294 | AA | 58 (35.6) | 69 (34.3) | 0.741 (0.599) | 1.00 | Referent |
| AG | 83 (50.9) | 99 (49.3) | 1.003 (0.636–1.580) | 0.991 | ||
| GG | 22 (13.5) | 33 (16.4) | 1.261 (0.663–2.397) | 0.480 | ||
| AG + GG | 105 (64.4) | 132 (65.7) | 0.830 (0.062) | 1.057 (0.685–1.630) | 0.803 | |
| A | 199 (61.0) | 237 (59.0) | 0.568 (0.327) | 1.00 | Referent | |
| G | 127 (39.0) | 165 (41.0) | 1.091 (0.809–1.470) | 0.568 | ||
CI, confidence interval; OR, odds ratio.
a p value for genotype and allele frequencies in cases and controls using 2-sided χ2 test.
b p values adjusted by age and gender using logistic regression.