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. 2017 May 4;2(9):e91625. doi: 10.1172/jci.insight.91625

Figure 4. RV miR-21 is upregulated in children with PI+PS and is associated with increasing fibrosis.

Figure 4

(A) RV miR-21 expression is upregulated in children with PI+PS (n = 4) and end-stage RV failure (n = 2) compared with those with mild RVOTO (n = 3) and infants with unrepaired TOF (n = 7). (B and C) Increasing fibrosis is seen in children with PI+PS (n = 4) and end-stage RV failure (n = 2). Scale bar: 100 μm. RV, right ventricle; RVOTO, RV outflow tract obstruction; TOF, tetralogy of Fallot; PI+PS, pulmonary insufficiency and pulmonary stenosis. Data are presented as mean ± SEM. ANOVA with multiple testing correction was used. Correlation was assessed using Pearson’s correlation. *P < 0.01, **P < 0.001.