Skip to main content
. 2017 May 4;2(9):e91981. doi: 10.1172/jci.insight.91981

Figure 6. BAT transplantation derived from BH4-sufficient mice improves BAT function as well as ameliorates glucose intolerance and insulin resistance in BH4-deficient mice.

Figure 6

Fed blood glucose levels (A; n = 6–7), intraperitoneal glucose tolerance test (IPGTT; 1 g/kg glucose) after 16 hours fasting (B; n = 6–7), insulin tolerance test (ITT; 1 unit/kg regular insulin) after 6 hours fasting (C; n = 6–7), pyruvate tolerance test (PTT; 1 g/kg pyruvate) after 16 hours fasting (D; n = 6–7), liver triglyceride (TG) and total cholesterol (T-CHO) content (E; n = 6–7), liver weight (F; n = 6–7), and plasma TG concentration (G; n = 6–7) in hph-1 mice transplanted with 0.1 g brown adipose tissue (BAT) derived from hph-1 mice (BH4-deficient mice) or control mice of the same background (BH4-sufficient mice) under high-fat diet for 20 days from the age of 8 weeks. Values are mean ± SEM. Statistical analysis was performed by 2-way ANOVA with Bonferroni post-hoc test (B–D) or Student’s t test (A, C, E–G). *P < 0.05, **P < 0.01 vs. hph-1 mice transplanted BAT derived from hph-1 mice.