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. Author manuscript; available in PMC: 2017 May 3.
Published in final edited form as: J Comp Neurol. 2012 Aug 15;520(12):2630–2646. doi: 10.1002/cne.23056

Figure 7.

Figure 7

Effect of post-SCI administration of 17β-estradiol on skilled locomotion. Skilled locomotion was assessed by the horizontal ladder test and quantified as percent correct forepaw placement at baseline (day 0) and on post-injury days 7–49. A: At baseline all animals had nearly 100% correct paw placements and animals in the Lam group maintained near this percentage for the duration of the experiment. A significant reduction in the percent correct paw placements was observed in the SCI group versus the Lam group on post-SCI days 7–49 (indicated by *). A significant increase in the percent of correct paw placements was observed in the E2 0.5 group as compared with the SCI group on post-SCI day 14 and 49 (indicated by **). B: A significant increase in the percent correct paw placements was found in the E2 5.0 group as compared with the SCI group on post-SCI day 49 (indicated by **). Note that data from Lam and SCI groups are duplicated from (A) for comparison. C: A significant decrease in the percent correct paw placements was observed in the ICI group as compared with the E2 5.0 group on post-SCI days 42 and 49 (indicated by +). Note that data from the E2 high group are duplicated from (B) for comparison.