A, Chemical structure of puerarin. B and C, Effects of puerarin on the body weights and fasting glucose levels in db/db group mice. D, After a 55-day treatment, IPGTTs were performed after a 12-hour fast with 2-mg/g BW of glucose in control, puerarin-, or vehicle-treated 12-week db/db mice. E and F, Effects of puerarin on the body weights and fasting glucose levels in HFD group mice. G, After a 35-day purarin treatment, IPGTTs were performed in control, puerarin-, or vehicle-treated 17-week HFD mice; *, P < .05; **, P < .01 puerarin to vehicle treated. Data are shown as mean ± SE, n = 12.