A–D, Puerarin modulated serum total CHO (cholesterol), TG (triglyceride) levels of db/db and HFD mice. E–G, Beneficial effects of puerarin on serum leptin and adiponectin levels of db/db and HFD mice. Data are shown as mean ± SE, n = 9; *, P < .05; **, P < .01 db/db to WT or HFD to ND; #, P < .05; ##, P < .01 puerarin to vehicle.