Figure 2. PELP1 as a scaffolding protein.

PELP1 interacts with SRs such as AR, ER, and PR through its LXXLL motif, SR coregulator proteins such as FHL2, p300, CBP, and Src, and chromatin-modifying proteins such as KDM1, coactivator-associated arginine methyltransferase 1 (CARM1), and histones through its glutamic acid-rich region. The interactome of PELP1 enables cross talk between these proteins and with the DNA.