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. 2015 Jul 9;29(9):1222–1229. doi: 10.1210/ME.2015-1049

Figure 3. Role of PELP1 in SR signaling.

Figure 3.

SR bound to PELP1 is translocated into the nucleus, where it binds chromatin. PELP1 facilitates transcription of SR-regulated genes by recruiting coregulators p300, CBP, and HAT to the chromatin that displace histone H1, and by interacting with KDM1 that causes methyl modifications on histone H3. In the absence of ligand, PELP1 may couple an unliganded SR to a liganded SR and activate genomic signaling. In the cytoplasm, PELP1 interacts with both Src and SRs. However, the role of PELP1 in nongenomic signaling needs to be robustly validated.