Figure 2.

Mean and standard deviation of the (A) CWS checklist (MWC score according to previous studies24,26,37) and (B) the Clinical Global Impression Scale (CGI-S Score80) during the course of the study. Reduced sample sizes on day 12 (n=35) and day 16 (n=28) due to regular dismissals and missed assessments are indicated by dashed lines. The effect size according to Cohen (Cohen’s d) was 1.1 for the CWS (day 1 to day 16), Cohen’s d ≥0.8 is defined to reflect a strong effect.130 Vertical imaginary Y-axis: severity scores. Horizontal imaginary X-axis: time course.

Note: Reproduced from Drug Alcohol Depend, 143, Bonnet U, Specka M, Stratmann U, Ochwadt R, Scherbaum N, Abstinence phenomena of chronic cannabis-addicts prospectively monitored during controlled inpatient detoxification: cannabis withdrawal syndrome and its correlation with delta-9-tetrahydrocannabinol and -metabolites in serum, 189–197. Copyright (2014), with permission from Elsevier.36

Abbreviations: CWS, cannabis withdrawal syndrome; MWC, Marijuana Withdrawal Checklist.