Table 5.

Time to onset of ADRs related to radiocontrast agents during 2014–2015

Investigation items	2014		2015		2014 and 2015
	n	Time to onset of ADRs (min)	n	Time to onset of ADRs (min)	n	Time to onset of ADRs (min)
Patients with allergy history or atopy traits	42	20.36±55.07a	27	12.08±8.61	69	17.19±43.59a
Patients without allergy history or atopy traits	138	115.56±280.20	107	46.73±210.48	245	85.34±253.82
Iodixanol	35	323.77±386.17b	0		35	323.77±386.17b
Non-iodixanol iodinated radiocontrast*	135	40.30±171.90	115		250	42.36±186.61
Time to onset of ADRs
≤5 min	38.89% (70/180)		35.07% (47/134)		37.26% (117/314)
5–30 min	41.11% (74/180)		54.48% (73/134)c		46.82% (147/314)
>30 min	19.44% (35/180)e		11.19% (15/134)c,e		15.92% (50/314)e
>1 h	13.89% (25/180)e		3.73% (5/134)d,e		9.55% (30/314)e

Notes:

^*Non-iodixanol iodinated contrast medium included iopamidol, iohexol, iopromide, and ioversol. Student’s t-test,

^aP<0.01 (patients with allergy history or atopy vs patients without allergy history or atopy),

^bP<0.01 (iodixanol vs non-iodixanol iodinated contrast medium),

^cP<0.05,

^dP<0.01 (2014 vs 2015),

^eP<0.01 (>1 h vs ≤5 min or >30 min vs ≤5 min). Data presented as mean ± standard deviation unless stated otherwise.

Abbreviation: ADR, adverse drug reaction.