Fig. 1.

Structure of Monomeric gp120 Post-Translationally Modified with High-Mannose Glycans with a Representative High-Mannose Schematic. A) The crystal structure of glycosylated gp120 monomer from HIV-1 clade G using the coordinates from PDBID: 5FYJ. gp120 is rendered in cartoon with surface in grey. The glycans are rendered in light green and red. The glycan positions rendered in red have been demonstrated to affect antiviral lectin activity of GRFT, CV-N, and SVN. B) Schematic of high-mannose for definition and discussion purposes. GlcNAc and mannose are represented as blue squares and green circles, respectively. The branches of the high-mannose structure are referred to as D1 for mannose 2–4, D2 for mannose 6 and 7 and D3 for mannose 8 and 9.