Fig. 3.

Representative Solution and Crystal Structures of Antiviral Lectins. X-ray crystal structures with resolved saccharides in the CRD were selected when possible. NMR solution structures were selected when no crystal structures were available. The N and C termini are represented as spheres and colored blue and red, respectively. The overall folds are rendered in white with the residues that participate in CRD highlighted in red and side-chains shown as sticks. The saccharides are represented as sticks and colored according to atom. The high-mannose schematic displays interaction positions in red as identified from the literature. GRFT: The engineered monomeric form of the lectin is shown with the WT domain swapped portion in orange. The inserted GS residues are rendered as black spheres. ConA: The dimer is shown, with the monomer that bound saccharide as white and the apo monomer as black.