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. 2017 Mar 18;142:37–54. doi: 10.1016/j.antiviral.2017.03.007

Table 4.

Structural class and glycan specificity of plant-derived antiviral lectins.

Lectin Mol. Wt. (kDa) Oligomeric status Structure class Glycan specificity Glycoprotein bound References
Jacalin 16.5 4 β-I Galβ(1,3)GalNAc and Promiscuous (G1 or G2) CD4* (Bourne et al, 2002, Sankaranarayanan et al, 1996, Jeyaprakash et al, 2003, Favero et al, 1993, Corbeau et al, 1994, Corbeau et al., 1995)
BanLec (WT) 30 2 β-I α(1,2), α(1,6) mannotetrose and Man9 (D3) gp120 (Koshte et al, 1990, Singh et al, 2005, Meagher et al, 2005, Swanson et al, 2010, Swanson et al, 2015)
GRFT (WT) 12.7 2 β-I α(1,2)mannobiose (M4, 7, 9) gp120 (Moulaei et al, 2010, Ziolkowska et al, 2006, Moulaei et al, 2015, Zappe et al., 2008)
SCL 13.1 4 β-II α(1,3:1,6)-mannotriose (Core) HIV (Wright et al, 1996, Wright et al, 1999)
NPL 12.0 4 β-II α1-3 or α1-6 linked mannoses (Core) HIV (Sauerborn et al, 1999, Marchetti et al, 1995, Balzarini et al, 1991, Weiler et al, 1990)
GNA 12.5 4 β-II α1-3 or α1-6 linked mannoses (Core) gp120 (Hester et al, 1995, Balzarini et al, 1991, Shibuya et al, 1988, Wright et al., 1990, Hester and Wright, 1996, Wright and Hester, 1996)
HHA 12.5 4 β-II Man5GlcNAc2 gp120/gp140 (Kaku et al, 1990, Hoorelbeke et al, 2013, Chantalat et al, 1996)
PCL 12.0 2 β-II α1,3dimannoside (Core) HIV (An et al, 2006, Ding et al, 2010)
ConA 25 4 ConA-Like Man9GlcNAc2-type (D1 or D3) gp120/gp41 (Sumner et al., 1935, Sawyer, 1975, Hardman and Ainsworth, 1972, Naismith et al, 1994, Kornfeld and Ferris, 1975, Pashov et al, 2005)
UDA 8.5 1 Hevein-Like GlcNAc4 (G1 G2) gp120/gp41 (Shibuya et al, 1986, Harata and Muraki, 2000, Saul et al, 2000)
MHL 9.2 Unk Hevein-Like GlcNAc (G1 G2) gp120 (Charan et al., 2000)
NICTABA 19 2 Unk GlcNAc (G1 G2) Gp41/120 (Gordts et al., 2015)