Figure 8. ERRα is essential for skeletal muscle fitness.
Schematic representation of biological processes coordinated by ERRα in exercise-induced muscle remodeling. Our model includes the well-characterized exercise-induced expression of the ERRα coactivator PGC1-α, also observed in this study (Supplemental Figure 4). All genes described in this figure are known direct transcriptional targets of ERRα (Supplemental Table 5).