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. 2014 Nov 12;28(12):1961–1970. doi: 10.1210/me.2014-1135

Figure 6. TA3 stimulates the maturation of PV-immunoreactive neurons in the somatosensory and retrosplenial cortex.

Figure 6.

Coronal forebrain sections of WT and Pax8-KO mice at P12 were immunostained with an antibody against PV that labels a subset of GABAergic interneurons. PV immunoreactivity was quantified on 3 consecutive sections from each animal using 4 animals per genotype and normalized to the respective cortical area. In saline-treated Pax8-KO mice, PV immunoreactivity was strongly reduced but could be partially restored upon TA3 treatment. Scale bar, 50 μm. **, P < .01; ***, P < .001. Abbreviation: AU, arbitrary unit.