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. 2014 Jul;28(7):1166–1185. doi: 10.1210/me.2013-1403

Figure 6.

Figure 6.

PRMT2-dependent gene signature is associated with DMFS. A–C, K-M survival analysis of breast cancer patients was conducted in NKI, TRANSBIG, and UNT cohorts showing high and low PRMT2_Total expression average score. A significant log rank test P value was obtained. D–F, K-M survival analysis of breast cancer patients was conducted in NKI, TRANSBIG, and UNT cohorts showing high and low PRMT2_DOWN expression average score. A significant log rank test P value was obtained. G–I, K-M survival analysis was performed using PRMT2_UP signature in NKI, TRANSBIG, and UNT cohorts. No significant log rank test was obtained. J, Concordance index was computed with the PRMT2_DOWN signature in five cohorts. K, Overall concordance index was generated with the combined data set to compare present breast cancer predicting signatures (NPI, GGI, and GENIUS) against PRMT2_DOWN signature using the genefu package. Broken red line (concordance index = 0.5) indicates no predictive ability. A value of 0 or 1 indicates perfect separation of patients with survival outcomes. Overall concordance index scores were plotted with lower and upper 95% confidence interval (CI) in the forest plot.